Healthy Bacteria In Gut – How to restore gut flora and reset your gut after antibiotics, Gut brain axis and probiotics, Lifestyle changes for a healthier microbiome, Ways to improve gut health, Allergy, the immune gut interplay, On the record
Red meat and cholesterol may not be the most harmful to your heart. How bacteria in your gut can interact with food
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Healthy Bacteria In Gut
Cleveland Clinic researchers were shocked by the news years ago. This month, they unveiled another surprise: By changing the gut bacteria, it is possible to treat or prevent heart disease caused by diet. So far, he has been working on laboratory mice.
Healthy Aging: Gut Bacteria May Prevent Disease
“The idea that gut bacteria help not only atherosclerosis but also heart attack and chronic kidney disease opens up new nutritional and intervention perspectives,” says Stanley Hazen, MD, PhD, Head of Preventive Cardiology and Rehabilitation.
Your digestive system is full of bacteria. Some of them are fed choline and carnitine, red meat, egg yolks and fatty dairy products. When they feed, they produce a chemical called TMA (trimethylamine). Your liver converts TMA into TMAO (trimethylamine-
TMAO in your blood affects the inner layer of your blood vessels, leading to the formation of cholesterol. If you have chronic high TMAO, your risk of heart attack, stroke and death is doubled. Studies show that the level of TMAO in your blood helps to predict the risk of heart disease.
So, if TMAO is harmful, how can we get rid of it? One way is to stop the intestinal bacteria from producing TMA.
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A new study by Dr. Hazen and his team found that the natural substance DMB (3, 3-dimethyl-1-butanol) can do this in mice. The result is a low TMAO level and low congestion arteries.
“We have been able to show that microbiome is an effective way to prevent heart disease from drug addiction,” says Dr. Hazen. “It’s very similar to using statins to stop the production of cholesterol in the cells of the body.”
DMB is found in some olive and grape oils. Because it is not an antibiotic, DMB does not kill “good bacteria”. Unlike antibiotics, there is little risk of developing overuse or resistance to them.
“Hopefully, along the way, this approach to reducing TMAO can be used to strengthen other ways to reduce cardiovascular events,” says Dr. Hazen.
How Good Bacteria Can Help Keep A Gut Healthy
“Omnivores usually have a higher TMAO rating than vegetarians and vegetarians, but not always,” he says. “TMAO levels are determined by your gut microbes rather than your diet. Other factors also play a role, such as the germs you encounter and other aspects such as kidney function and genetics. “
Cleveland clinical researchers have shown that controlling the bacteria in your gut can help prevent heart disease-related diets. The substance contained in olive oil and grape oil can be treated. New research reveals a cellular mechanism by which good bacteria can help keep the gut healthy. A study published in the Journal of Immunity shows that good bacteria, or microbiota, interact with intestinal epithelial cells and immune system cells to balance immune responses and prevent the gut from becoming inflamed. The study suggests that manipulating microbiota to limit intestinal immune responses can have potential therapeutic benefits for conditions such as intestinal disease.
“Currently, the important body is modulating the microbiota immune system and helping it do its job,” said the relevant author, Dr. Gretchen Dieh, professor of molecular virology and microbiology, director of biology at the Center for Inflammation and a member of the Dan L Duncan Center for Integrative Oncology at Bailor Medical College. “Microbes that cause diseases such as salmonella cause a strong inflammatory immune response aimed at destroying the germ. However, an inflammatory immune response, especially the gut, can damage healthy tissues.
For an effective immune response, immune cells called antigen-presenting cells, as well as other immune cells called T cells, are directed to put in place appropriate inflammatory measures to fight microbial invasion. They also call anti-inflammatory T cells, as well as regulatory T cells, to limit inflammatory immune responses to things like the food we eat and to extinguish inflammatory immune responses.
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Microbiota antigen-presenting cells help the cells to “modulate” the inflammatory response by asking them to release the IL-10 cytokine, which is an important anti-inflammatory molecule. IL-10 reduces inflammatory responses of T cells and promotes responses that regulate T cells that protect homeostasis.
“The result is a balm-like response, which can still fight infections like salmonella, but is modulated to prevent damage to healthy tissue,” Dihl said. “We wanted to know if the microbiota could cause such reactions.”
“When we gave antibiotics to animals, we found that the antigen-presenting cells did not produce IL-10. “Once we put the bacteria in the animal’s intestines, only bacteria that can stick to the intestinal epithelium stimulate the cells that produce antigen-presenting IL-10 and reduce the inflammatory response,” Diehl said. “It’s a bit of a continent because microbes that can cling to the intestinal epithelium are considered pathogens that can cause disease.
Investigators say their research is just scratching the surface, and they are actively looking for other mechanisms that can create a microbial-balanced gut environment.
Intestinal Health Archives
Further, Diehl and colleagues also plan to examine signaling pathways that are activated when microbes cling to epithelial cells in order to identify new pathways for a balanced immune response.
“The message for us is that a healthy microbiota is important not only to protect us from infection, but also to limit the potential damage to tissues when the immune system is trying to eliminate pathogens,” Diehl said.
More information: Munghu Kim et al., CX 3 CR1 + Critical Role for Microbiota + Regulatory Response of Intestinal Mononuclear Phagocyte Intestinal T Cells, Immunity (2018). DOI: 10.1016 / j.immuni.2018.05.009
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Engineered Bacteria Could Help Protect “good” Gut Microbes From Antibiotics
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MIT researchers have developed a group of bacteria called L. lactis spTEM1 in the picture, which helps protect the natural plants of the human digestive tract from antibiotics and prevent the development of opportunistic infections such as C. difficile.
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Antibiotics are life-saving drugs, but they can also harm beneficial microbes living in the human gut. After being treated with antibiotics, some patients are at risk for inflammation or opportunistic infections.
To mitigate these risks, MIT engineers have developed a new way to protect the natural plants of the human digestive system. They took a group of bacteria that were safe for human consumption and produced a safe enzyme that destroys a class of antibiotics called beta-lactam. These include ampicillin, amoxicillin and other commonly used drugs.
When given in conjunction with “living biotherapeutic” antibiotics, it protects the intestinal microflora, but allows high levels of blood-circulating antibiotics, the researchers said.
“It simply came to our notice then.
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