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The secret to successful aging may be in your gut, according to a new report. The study found that it is possible to predict that you can live a longer and healthier life by looking at the trillions of bacteria, viruses and fungi that live in your gut.
The new study, published in the journal Nature Metabolism, found that as people get older, the complex structure of this microbiome, called the microbiome, changes. With many changes, better, it seems.
Changing Your Gut Bacteria
In healthy individuals, the species that control the gut in adulthood tend to have smaller microbial populations over the next decade, while the proportion of other species usually increases slightly. But in less healthy people, according to the study, something different happens: The composition of their microbiome remains small and they die early.
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New research shows that the gut microbiome, which is constantly changing as you grow older, is a sign of successful aging, says study author Sean Gibbons, a microbiologist and associate professor at the Institute for Systems Biology in Seattle. Biomedical research appointments are free.
“Most research on aging is about getting people back to the small state or turning the clock around,” he said. But the conclusions are very different. Probably a good microbiome for a 20-year-old is not good at all for an 80-year-old. It seems good to have a flexible microbiome when you grow up. It means that the stress on your system changes quickly in the aging body.
Researchers could not be sure if changes in the gut microbiome were contributing to aging. But they also saw signs that what was happening over the years could improve people’s health. For example, they found that microbiomes that altered certain profiles as they grew older also had higher levels of compounds that promote good health in their blood, including compounds that produce germs against disease.
Scientists have long believed that the microbiome plays a role in aging. Studies have found, for example, that adults aged 65 and over who are less active and more active have a higher risk of developing certain germs in their gut compared to older people who are less healthy and healthier. People develop early signs of weakness and experience different types of microbial age. By studying the microbiomes of people of all ages, scientists have discovered a system that prolongs life expectancy. The microbiome undergoes rapid changes as it develops within the first three years of its life. Then it stays relatively good for decades, before gradually making changes to its makeup as people reach middle age, which accelerates aging and the body is stronger and slower or remains stable and unhealthy.
A Changing Gut Microbiome May Predict How Well You Age
Although no two microbes are the same, humans share about 30 percent of their bacterial population. The few common and abundant forms are the “core” of the gut microbes in all of us, as well as small amounts of other species found in different collections, different from all the others.
To gain a better understanding of what happens in the gut as people get older, Dr. Gibbons and associates, including Drs. Tomasz Wilmanski, who led the new study, looked at data from more than 9,000 adults who have their own microbiome. . Their age ranges from 18 to 101 years.
About 900 of them are elderly people who regularly visit the clinic to check their health. Dr. Gibbons and his colleagues found that in the middle of life, starting at about 40, people began to show variations in their microbiomes. The nerves most affected in their gut fall off, while others, less common, become worse, causing their microbiomes to change and look different from other people and humans.
“What we’ve found is that over the course of decades, people move – their microbiomes become more and more unique to each other,” he said. said Gibbons.
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Those with the most changes in their microbial configuration often enjoy better health as well as longer life. They have high levels of vitamin D as well as low levels of LDL and triglycerides, a type of fat in the blood. They need less medication and have better physical health, faster running and greater mobility.
The researchers found that these “extracts” also had high levels of many metabolites in their blood produced by germs, including indoles, which have been shown to reduce inflammation and maintain the integrity of the body’s immune system that protects and protects the intestines. In some studies, scientists have found that giving indole to mice and other animals helps them stay young, allowing them to stay active, move and be resistant to disease, injury and other stress in old age. One of the metabolites discovered in this new study is phenylacetylglutamine. It is not clear what the park does. However, some experts believe that it promotes longevity, because research has shown that consumers in northern Italy often have higher levels.
Dr. Wilmanski found that the gut microbiome changed little to no as they grew older. They have high cholesterol and triglycerides and low levels of vitamin D. They do not work very hard but can not walk fast. They use other drugs and almost twice as many people die during the study.
The researchers said that some intestinal disorders that can be serious or perhaps even beneficial in childhood can become harmful in old age. For example, the study found that among healthy people who saw significant changes in the structure of their microbiome, there was a significant reduction in the number of bacteria called Bacteroides, which are common in urban countries where people eat highly organized food. fats, sugars and salts, and which is usually low in developing countries where people eat a lot of fiber. When the cable is missing, Dr. Gibbons said Bacteroides like to “blow their noses”, including a protective coating that encloses the intestines.
Gut Bacteria Might Guide The Workings Of Our Minds
“Maybe it’s okay when you’re 20 or 30 and it produces a lot of noses in your gut,” he said. “But as we get older, our noses become more important. Maybe we can stop this suffering.”
If germs suffer from a barrier that protects them in the gut, they are likely to trigger a response in the immune system.
“When that happens, the immune system is very successful,” he said. said Gibbons. “Having a diaper is like having a detoxifying substance that allows us to live happily with our germs, and if that goes away, a war breaks out” and can stop inflammation and – forever. Increasingly, chronic inflammation is thought to cause many age-related diseases, from heart disease and diabetes to cancer and arthritis.
One way to prevent these germs from damaging the lining of the intestines is to give them something else to eat, such as fiber from whole foods such as beans, nuts and fruits and vegetables.
How Your Gut Might Modify Your Mind
Other studies have shown that diet can have a significant effect on the structure of the microbiome. Although the new findings are unlikely to have a positive effect on the effects of different foods on the microbiome as we age, Dr. Gibbons said he expects to review it in future studies.
“It is possible to maintain the aging layer in the intestines by increasing the amount of fiber in the diet,” said Dr. said Gibbons. “Either we can find other ways to reduce the amount of Bacteroides or increase indole production from food. These are not future help we hope to try.”
Meanwhile, he said, his advice to people is to try to exercise, which can have a beneficial effect on the gut microbiome, and eat more fiber and fish with a balanced diet.
He says: “I have been eating a lot of fiber since I started studying the microbiome. “Whole foods such as fresh fruits and vegetables contain all the complex carbohydrates that our germs like to eat. So when you eat, think of your germs. ” In the recent past, it was common for mental illness or neurological disorders to be characterized as negative thoughts. Headaches and chronic pain are considered normal parts of life. There are other situations like the one we have not fully understood for a long time.
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As evidence emerges that our perception of what is going on in the gut increases, it becomes clear that the health of our gut largely determines many other aspects.
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